Serum Levels of Calcium, Albumin, Globulin, and Matrix Metalloproteinase-9 in Patients with Acute Cerebral Infarction

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Case of the world J Clin. October 26, 2021; 9 (30): 9070-9076. doi: 10.12998 / wjcc.v9.i30.9070.

ABSTRACT

Background: Hemorrhagic transformation (HT) is a common complication in patients with cerebral infarction. However, its pathogenesis is poorly understood. Knowing the factors that may increase the risk of HT can help improve the safety of thrombolytic therapy.

AIM: To study the predictive value of serum calcium, albumin, globulin and matrix metalloproteinase-9 (MMP-9) levels for HT after intravenous thrombolysis (IVT) in patients with acute cerebral infarction.

Methods: Five hundred patients with acute cerebral infarction who received IVT with alteplase within 4.5 hours of disease onset between January 2018 and January 2021 in our hospital were selected as study subjects. They were divided into groups based on the results of brain CT scans performed within 36 hours of thrombolysis. Forty patients with HT were included in an observation group and 460 patients without HT were included in a control group. Serum calcium, albumin, globulin and MMP-9 levels were compared between the two groups. Regression analysis was used to discuss the relationship between these indices and HT.

RESULTS: History of hypertension, diabetes, atrial fibrillation, cerebrovascular disease, smoking, and alcohol consumption were not associated with HT after TTI in patients with acute cerebral infarction (all P > 0.05). The National Institutes of Health (NHISS) Stroke Scale score has been associated with HT after IVT in patients with acute cerebral infarction (P P P P

Conclusion: Serum calcium, albumin, globulin and MMP-9 levels are risk factors for HT after TTI in patients with acute cerebral infarction. In addition, the NHISS score can be used as a predictor of post-thrombolytic HT.

PMID: 34786389 | PMC: PMC8567529 | DOI: 10.12998 / wjcc.v9.i30.9070

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