Matrix metalloproteinase 12 is an independent prognostic factor predicting postoperative relapse of conventional renal cell carcinoma – a brief report

Oncol cell (Dordr). December 11, 2021. doi: 10.1007 / s13402-021-00650-9. Online ahead of print.

ABSTRACT

OBJECTIVE: Approximately 15% of clinically localized conventional renal cell carcinomas (cRCCs) metastasize within 5 years of follow-up. Sarcomatous cRCC is a highly malignant cancer of the kidney. The aim of our study was to identify biomarkers to estimate the postoperative progression of CRCc.

METHODS: Global gene expression analysis based on RCC DNA microarrays with and without sarcomatous changes revealed that high expression of MMP12 was associated with sarcomatous histology. In addition, we analyzed the expression of MMP12 using a multi-tissue matrix comprising 736 cRCC patients without metastasis at the time of surgery. The median duration of follow-up was 66 ± 29 months.

RESULTS: Immunohistochemistry revealed expression of MMP12 in 187 of 736 cRCCs with good follow-up data. A subsequent Kaplan-Meier analysis revealed that patients with MMP12 positive tumors had significantly shorter tumor-free survival (p

CONCLUSIONS: MMP12 can serve as a biomarker to estimate postoperative relapse of CRCC and as a possible target for penfluridol treatment.

PMID: 34894337 | DOI: 10.1007 / s13402-021-00650-9